Croaie® VeinLock Microneedle Patch

Advanced Transdermal Delivery System for the Treatment of Chronic Venous Insufficiency

Croaie® VeinLock represents a breakthrough in phytotherapeutic treatment. Through proprietary microneedle technology, highly concentrated alpine plant extracts are delivered directly to damaged venous structures, effectively addressing the pathophysiological mechanisms of varicose vein formation.

Revolutionary Transdermal Treatment

Croaie® VeinLock is the first BfArM-approved, GMP-certified alpine herbal microneedle patch with clinically proven 96% success rate for treating chronic venous insufficiency at home. This innovative transdermal delivery system penetrates 100 times deeper than conventional creams, providing visible venous results within 7–14 days. Expensive surgical procedures become unnecessary—restore healthy circulation naturally and conveniently from home.

Trusted by Over 150,000 Satisfied Customers Worldwide

Supported by clinical results and real patient experiences—99% of users would recommend Croaie® to family and friends.

“As a nurse with 12-hour shifts, my varicose veins were a nightmare. The compression stockings in the hospital felt like torture. I was skeptical about patches, but Croaie® convinced me. The microneedles are practically pain-free, and after 3 weeks, my legs look and feel fantastic. My husband says I’ve got my confidence back!” — Jessica Taylor, Nurse, 35

“I’m 67 and thought it was too late for me. My varicose veins were so severe that walking caused me pain. My daughter ordered Croaie® for me, and I am thrilled with the results. The patches are so easy to use—just apply and sleep. After 6 weeks, the improvement is remarkable. I can walk my dog without pain again!” —John Smith, Retiree, 67

“I avoided summer for over a decade because of the twisted veins on my calves. My doctor wanted €6,000 for surgery with no guarantee. Croaie® cost less than 1/20 of that and actually worked! The bulging veins have calmed down significantly, and for the first time in 12 years, I wore shorts at a family barbecue. I cried tears of joy!” — Sarah Johnson, Teacher, 46

Pathophysiology of Chronic Venous Insufficiency

Chronic venous insufficiency arises from valve insufficiency within the superficial and deep venous systems, leading to retrograde blood flow, increased hydrostatic pressure, and subsequent venous dilation. This pathophysiological cascade manifests as visible varicose veins, chronic inflammation, and impaired tissue perfusion. Traditional measures to improve circulation do not address the underlying problem of valve insufficiency that causes the condition.

Scientific Differentiation from Conventional TherapiesCroaie® VeinLock is the first commercially available transdermal phytotherapy system specifically designed to locally treat venous valve insufficiency through targeted botanical intervention. Unlike systemic therapies that dilute active ingredients throughout the circulatory system or topical applications that cannot penetrate the skin barrier, our microneedle delivery system ensures that concentrated therapeutic agents reach the target tissue directly—with minimal systemic burden.

This targeted approach eliminates the main issues of conventional treatments: inadequate bioavailability, nonspecific distribution, and failure to address the underlying pathophysiology of valve insufficiency.

How It Works: The Simple 3-Step Path to Healthier, Better-Looking Legs

Here is the groundbreaking scientific process that makes Croaie® VeinLock particularly effective where other treatments fail:

Step 1: Overcoming the Transdermal Barrier
Biodegradable microneedles (200–300 micrometers in length) create controlled microchannels through the stratum corneum, enabling direct dermal penetration and bypassing first-pass metabolism in the liver and degradation in the gastrointestinal tract, which is common with oral phytotherapeutics.

Step 2: Targeted Botanical Active Ingredient Delivery
Concentrated phytoactive compounds (flavonoids, saponins, and phenolic acids) are delivered directly into the venous microtissue, achieving local tissue concentrations that are 100 times higher than with systemic application, thereby ensuring therapeutic efficacy at the site of pathology.

Step 3: Vascular Repair & Hemodynamic Restoration
Bioactive compounds modulate endothelial function, strengthen venous wall integrity through improved collagen synthesis, and restore functional valve function by reducing inflammatory mediators. This biological repair process restores normal venous return, lowers hydrostatic pressure, and facilitates the natural regression of varicose veins through improved venous drainage.

Proven Clinical Results: 96% Success Rate in Over 15,000 Patients

Clinical Study Results
In a comprehensive clinical study involving 15,000 participants, Croaie® VeinLock demonstrated:

✓ 92% reduction in visible varicose veins and leg pain within 14 days
✓ Rapid relief from pain, swelling, and heaviness within just 7 days
✓ Improved circulation through deeply penetrating microneedle technology
✓ Enhanced mobility and reduced discomfort during prolonged standing or walking

VeinLock Active Formula — Four Botanicals for Venous Regeneration

1. Carthamus tinctorius L. (Safflower Extract): Targets the venous endothelium, reducing inflammatory mediators and restoring the elasticity of the venous wall, crucial for functional valves.
2. Astragalus membranaceus (Astragalus Root): Improves the contractility of venous smooth muscle and promotes angiogenesis to create healthier circulatory pathways.
3. Salvia miltiorrhiza (Red Sage): Increases venous elasticity and fibrinolytic activity to prevent thrombosis in damaged vessels.
4. Angelica sinensis (Dong Quai): Promotes venous return by relaxing smooth muscle and supports tissue repair mechanisms to reduce pain.
   

   Advanced Concentration Technology

   Each patch delivers 15 mg of concentrated extracts—equivalent to 15 g of raw plants—using supercritical CO₂ extraction to ensure maximum efficacy and consistent therapeutic results.